European journal of anaesthesiology
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Anaesthetic preconditioning (APC) exerts cardioprotective effects by reducing infarct size and improving recovery of contractile function after ischaemia-reperfusion. The interval between brief exposure to volatile anaesthetic and sustained ischaemia, the acute memory phase, is dependent on intracellular signalling mediating this cardioprotection. Intramyocyte translocation of protein kinase C (PKC) is known to be a key mediator in APC. We examined the relationship between the time frame of the acute memory phase of sevoflurane preconditioning and intramyocyte translocation of PKC-alpha, delta and epsilon to the particulate fraction. ⋯ The acute memory phase of sevoflurane preconditioning is limited to less than 60 min. Sustained translocation of PKC-alpha and epsilon, but not delta, correlates with this acute memory phase of sevoflurane preconditioning.
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Randomized Controlled Trial Comparative Study
Effects of clonidine and midazolam premedication on bispectral index and recovery after elective surgery.
Alpha-2 agonists offer useful effects that make these drugs an interesting alternative for pharmacological premedication. ⋯ Clonidine augmented haemodynamic stability and partially blunted stress responses as determined by adrenocorticotropic hormone plasma levels. In addition, clonidine did not delay postoperative recovery. Therefore, surrogate parameters indicate that preanaesthetic medication with clonidine may be superior to midazolam in healthy individuals. Further studies have to confirm these results with regard to outcome parameters.
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Controlled Clinical Trial
Forced-air warming effectively prevents midazolam-induced core hypothermia in volunteers.
Midazolam is a commonly used sedative and anaesthetic adjuvant and the agent is known to decrease core temperature by core-to-periphery redistribution of heat. We tested the hypothesis that forced-air warming could effectively prevent midazolam-induced hypothermia. ⋯ We conclude that forced-air warming can effectively prevent midazolam-induced redistribution hypothermia.
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Letter Randomized Controlled Trial
Does topical application of adrenaline on nasal mucosa induce significant haemodynamic changes under general anaesthesia?
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Randomized Controlled Trial Comparative Study
Learning curves of the Glidescope, the McGrath and the Airtraq laryngoscopes: a manikin study.
Several video and optical laryngoscopes have been developed but few have been compared in terms of their learning curves and efficacy. Using a manikin with normal airways we compared the Glidescope, the McGrath, the Airtraq and the Macintosh laryngoscopes. ⋯ In a 'normal airway' model, intubation skills with the new devices appeared to be rapidly mastered. The three indirect laryngoscopes provided a better glottic exposure than the Macintosh. The Airtraq displayed the most favourable learning curve, probably reflecting differences in the techniques of endotracheal tube placement: guiding channel versus steering technique.