European journal of anaesthesiology
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Systemically administered lidocaine has been shown to have anti-inflammatory properties. Inhalation is an attractive way of application because of high pulmonary compound concentrations and potentially fewer systemic side effects. The aim of this study was to clarify whether inhaled or, likewise, intravenous lidocaine can attenuate the inflammatory response in a model of experimental endotoxaemia in the rat. ⋯ Pretreatment of endotoxaemic rats either with Lid(Ae4.0) or with Lid(iv) attenuated the levels of proinflammatory mediators in bronchoalveolar lavage fluid. Plasma cytokine levels were not affected. Nebulized lidocaine (0.4 mg kg(-1)) inhibited the nitrite release but did not affect the cytokine levels.
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Randomized Controlled Trial
The usefulness of the laryngeal mask airway Fastrach for laryngeal surgery.
Suspension laryngoscopy under general anaesthesia with a tracheal tube has been widely used for laryngeal microsurgery, but it has some limitations such as intense cardiovascular stimulation during anaesthesia of short duration, occasionally a poor surgical field, and the possibility of a mass being hampered by the tracheal tube. The aim of this study was to compare the usefulness of the laryngeal mask airway (LMA) Fastrach and fibreoptic bronchoscope with a conventional suspension laryngoscope in laryngeal microsurgery. ⋯ The LMA Fastrach during fibreoptic bronchoscope-guided laryngeal surgery provided a good surgical field and haemodynamic stability without additional risk compared with the conventional suspension laryngoscope.
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Randomized Controlled Trial
Learning fibreoptic intubation with a virtual computer program transfers to 'hands on' improvement.
Fibreoptic intubation is an essential skill in anaesthesiology that is challenging to learn in the clinical setting. The goal of this study was to evaluate 'virtual fibreoptic intubation' (VFI) software as an adjunct to the traditional fibreoptic intubation teaching. ⋯ Self-training in fibreoptic intubation with the VFI software may improve the acquisition of fibreoptic intubation skills.
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Randomized Controlled Trial
Laryngeal mask airway vs. uncuffed endotracheal tube for nasal and paranasal sinus surgery: paediatric airway protection.
Risks are anticipated for laryngeal mask airway (LMA) anaesthesia during nasal and sinus surgeries because blood can trickle posteriorly into the hypopharynx and contaminate the airway. This study was conducted to determine whether a LMA could provide adequate airway protection from the expected intraoperative bleeding. ⋯ LMA is a suitable method for paediatric patients undergoing sinonasal surgery because it offers airway protection from blood contamination comparable to that of a standard uncuffed ETT with throat pack.
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Randomized Controlled Trial
Effects of perioperative intravenous low dose of ketamine on postoperative analgesia in children.
Low dose of ketamine reduces postoperative pain and opioid consumption in adult studies. However, there are only a few data with controversial results in the paediatric population. The aim of this randomized controlled trial was to evaluate the use of low doses of intravenous ketamine on postoperative pain in children after surgery on the lower part of the body. ⋯ The study failed to show any evidence of benefit of ketamine to improve analgesia in children when given in addition to a multimodal analgesic therapy with paracetamol, a NSAID and an opiate.