European journal of anaesthesiology
-
A new minimally invasive metabolic test for the diagnosis of susceptibility for malignant hyperthermia measuring intramuscular p(CO(2)) and lactate following local application of caffeine and halothane in humans was recently proposed. The present study tested the hypothesis that a more simplified test protocol allows a differentiation between malignant hyperthermia susceptible (MHS) and malignant hyperthermia nonsusceptible (MHN) and control individuals. ⋯ Local caffeine and halothane injection increased intramuscular metabolism in MHS individuals significantly more than in the two other groups. In contrast to previous investigations, direct injection of the concentrations of halothane described here increased lactate and p(CO(2)) even in MHN skeletal muscle.
-
Comment Letter
Complications of hydroxyethyl starch in paediatric patients.
-
Patients commonly take a combination of prescription drugs and herbal medicines. Often these alternative products have known pharmacological effects which may interact with drugs given perioperatively, resulting in adverse events. They can also cause physiological fluctuations which may influence the choice of anaesthetic technique used. This has been acknowledged by a number of national bodies that recommend eliciting a history of herbal medicine use preoperatively. This survey attempted to ascertain whether this guidance had been observed and turned into local policy. We also attempted to determine what advice patients were being given. ⋯ Anaesthetic departments in the United Kingdom are not currently following national advice regarding herbal medicine use. There is no coherence in the advice being offered to patients in the perioperative period, which may reflect the lack of information available. National guidelines may help clinicians understand the issues and adopt best practice.