European journal of anaesthesiology
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Randomized Controlled Trial
Influence of preoperative oral rehydration on arterial plasma rocuronium concentrations and neuromuscular blocking effects: A randomised controlled trial.
The influence of preoperative rehydration on the action of rocuronium has not yet been investigated. ⋯ Preoperative rehydration significantly reduces arterial plasma rocuronium concentrations in the first 2 minutes after administration, prolonging the onset time and shortening the duration of effect. A higher dose or earlier administration should be considered for patients who receive preoperative rehydration.