European journal of anaesthesiology
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Clinical Trial Observational Study
Significance of new Q waves and their location in postoperative ECGs after elective on-pump cardiac surgery: An observational cohort study.
The clinical significance of new pathological Q waves after on-pump cardiac surgery is uncertain. ⋯ The current analysis suggests that for patients undergoing elective on-pump cardiac surgery, only new pathological Q waves in V1 to V5 (anterior) in the 7th postoperative day ECG are associated with 12-month, all-cause mortality and/or MACE.
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Randomized Controlled Trial
Time course of copeptin during a model of experimental pain and hyperalgesia: A randomised volunteer crossover trial.
A reliable biomarker for quantifying pain or hyperalgesia has yet to be found. A surrogate marker of arginine vasopressin, copeptin, is elevated in a number of states of physiological and psychological stress and may have a role in quantifying pain and/or hyperalgesia. ⋯ Copeptin concentrations do not appear to be associated directly with pain and hyperalgesia. Instead, some fentanyl-mediated effect or effects appear to have greatly increased copeptin concentrations from baseline to 120 min.
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Pleural effusion is a common finding in critically ill patients and may contribute to circulatory instability and the need for inotropic support. ⋯ In a porcine model of pleural effusion, dobutamine affected basic haemodynamic determinants substantially by decreasing left ventricular preload. Changes in central venous pressure and inferior vena cava characteristics were minimal, discouraging their use as indices of preload. This study underlines the significance of evaluating basic haemodynamic determinants to avoid inappropriate, potentially harmful treatment.