European journal of anaesthesiology
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Severe pandemic influenza has been associated with the hyperinflammatory condition secondary haemophagocytic lymphohistiocytosis (HLH). ⋯ Critically ill patients, including healthy young adults, with pandemic influenza may develop HLH and should be monitored for signs of hyperinflammation and increasing organ dysfunction, and evaluated promptly for HLH because HLH-directed therapy may then be beneficial. The association of low NK percentages with hyperferritinaemia may suggest a role for reduced NK cell numbers, possibly also cytotoxic T lymphocytes, and subsequently reduced lymphocyte cytotoxicity, in the pathogenesis of hyperinflammation and secondary HLH.
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Randomized Controlled Trial
Bilateral mid-axillary transversus abdominis plane block does not attenuate stress response to total abdominal hysterectomy: A randomised controlled placebo trial.
The hormonal response to surgical trauma can have detrimental effects on patients. Transversus abdominis plane (TAP) block, which can improve analgesia after total abdominal hysterectomy (TAH) might attenuate the peri-operative stress response. ⋯ ClinicalTrial.gov identifier: NCT03443271.
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Meta Analysis
Transversus abdominis plane block in urological procedures: A systematic review and meta-analysis.
Transversus abdominis plane (TAP) blocks have been shown to successfully reduce pain and opioid consumption after general and gynaecological surgery. ⋯ PROSPERO CRD42018112737.
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Meta Analysis
Pre-operative proteinuria, postoperative acute kidney injury and mortality: A systematic review and meta-analysis.
To investigate the association of pre-operative proteinuria with postoperative acute kidney injury (AKI) development as well as the requirement for a renal replacement therapy (RRT) and mortality at short-term and long-term follow-up. ⋯ CRD42020190065.