European journal of anaesthesiology
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Randomized Controlled Trial
Exploring cardiac effects after oxytocin 2.5 IU or carbetocin 100 μg: A randomised controlled trial in women undergoing planned caesarean delivery.
Oxytocin can stimulate release of myocardial biomarkers troponin I and T, prolong QTc and induce ST-depression. ⋯ Oxytocin 2.5 IU and carbetocin 100 μg caused a similar increase in QTc. The trial was underpowered with regards to ST-depression and the release of myocardial biomarkers and these warrant further investigation. Data from this trial will inform a larger phase 4 trial to determine potential drug differences in troponin release.
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Randomized Controlled Trial
Discharge readiness after remimazolam versus propofol for colonoscopy: A randomised, double-blind trial.
Remimazolam is an ultrashort-acting benzodiazepine that is potentially a practical option for procedural sedation in colonoscopy. ⋯ For sedation in ambulatory colonoscopy, compared with propofol, remimazolam provides a noninferior discharge time. Furthermore, remimazolam is associated with less injection pain, lower risks of hypotension and bradycardia, and improved patient satisfaction.