European journal of anaesthesiology
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Mitochondrial dysfunction is linked to the etiopathogenesis of postoperative delirium (POD), which severely affects the prognosis of elderly patients undergoing surgery. The methylation of mitochondrial DNA (mtDNA), a new and incompletely described phenomenon that regulates the structure and function of mitochondria, is associated with ageing. However, the relationship between mtDNA methylation and POD has not been established. ⋯ These data support the existence of epigenetic mtDNA regulation in POD; however, further studies are required to explore the specific mechanisms.
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Comment Letter
Injuries after cricothyroidotomy using different equipment.
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Meta Analysis
Association between night-time extubation and clinical outcomes in adult patients: A systematic review and meta-analysis.
Whether night-time extubation is associated with clinical outcomes is unclear. ⋯ Night-time extubation of adult patients was not associated with higher adjusted risks for reintubation or death, in comparison with daytime extubation, but the certainty of the evidence was low.