European journal of anaesthesiology
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Randomized Controlled Trial
Intra-operative infusion of esmolol and pain following mastectomy: A randomised clinical trial.
Esmolol is a beta-1 selective blocker that has been shown to reduce postoperative pain. Its antinociceptive effects have not been tested following mastectomy. ⋯ Esmolol was well tolerated, allowed a notable reduction in the dose of rescue analgesics and demonstrated superior efficacy compared to placebo for pain management after mastectomy.
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Randomized Controlled Trial
Bilateral mid-axillary transversus abdominis plane block does not attenuate stress response to total abdominal hysterectomy: A randomised controlled placebo trial.
The hormonal response to surgical trauma can have detrimental effects on patients. Transversus abdominis plane (TAP) block, which can improve analgesia after total abdominal hysterectomy (TAH) might attenuate the peri-operative stress response. ⋯ ClinicalTrial.gov identifier: NCT03443271.
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Previous studies have suggested that healthcare professionals may be susceptible to substance use disorders, and among the medical specialties, anaesthesia providers appear to be overrepresented. ⋯ High-to-moderate-certainty evidence shows that there is more than a two-fold increased rate of substance use-related mortality and suicide among anaesthesia providers compared with other healthcare professionals. Investigations examining substance abuse between healthcare professionals, with particular attention to working conditions and exposure are essential to further develop preventive strategies.
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Meta Analysis
Pre-operative proteinuria, postoperative acute kidney injury and mortality: A systematic review and meta-analysis.
To investigate the association of pre-operative proteinuria with postoperative acute kidney injury (AKI) development as well as the requirement for a renal replacement therapy (RRT) and mortality at short-term and long-term follow-up. ⋯ CRD42020190065.
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Randomized Controlled Trial Observational Study
Magnetic resonance imaging of cerebrospinal fluid spread in the epidural space correlates with the severity of postdural puncture headache in obstetric patients: A proof-of-concept study.
Currently, performing an epidural blood patch (EBP) for postdural puncture headache (PDPH) remains a subjective clinical decision. An evidence-based protocol may be of value in identifying women at high risk of developing a severe PDPH. ⋯ ISRCTN14959004, https://www.isrctn.com/.