European journal of anaesthesiology
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Letter Comparative Study
Comparing C-MAC videolaryngoscope with direct laryngoscopy for emergency intubation.
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Letter Randomized Controlled Trial Comparative Study
Comparison of polyvinyl chloride and tin stylets for postoperative sore throat and hoarseness: A randomised trial.
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Use of dipyrone (metamizole) in perioperative and ICU pain therapy remains controversial due to a lack of solid evidence weighing dipyrone benefit against its potential life-threatening complications. Although dipyrone has known analgesic and antipyretic properties, its mechanisms of actions are incompletely understood. Although dipyrone effects on renal vasodilator prostaglandin synthesis are documented, little is known about its potential renal side effects, especially in the critical care environment. ⋯ Increasing dipyrone dosage is a potential independent risk factor for AKI in adult ICU patients and may prolong vasopressor therapy. Clinical evidence for a benefit of dipyrone therapy in the ICU is insufficient and needs further critical evaluation.