Neuroscience research
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Neuroscience research · Feb 1996
Mild electrical stimulation of pontine tegmentum around locus coeruleus reduces rapid eye movement sleep in rats.
The norepinephrinergic neurons in the locus coeruleus (LC) cease firing during REM sleep (REMS) and increase firing during REMS deprivation. Most of the earlier studies used lesion and transection techniques which could not confirm the role of LC in REMS generation and/or its maintenance, if at all. Hence, in this study it was hypothesized that if the LC REM-off neurons must cease firing before the onset of REMS, its continuous activation should eliminate or at least reduce REMS. ⋯ Total duration of REMS was significantly reduced during stimulation and showed a rebound increase during the post stimulation period. This reduction in REMS duration was primarily due to a significant reduction in the REMS frequency/h while the mean REMS duration/episode was not affected. Thus, the results of this study suggest that the stimulated area (LC) affects REMS, most likely by suppression of REMS generation process.