Journal of hepatology
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Journal of hepatology · Aug 2007
Randomized Controlled TrialA randomized trial of antioxidant therapy alone or with corticosteroids in acute alcoholic hepatitis.
Oxidative stress is putatively involved in the pathogenesis of alcohol-induced liver injury. This trial was devised to determine whether antioxidant therapy, alone or as an adjunct to corticosteroids, improved survival in patients with acute alcoholic hepatitis. ⋯ Antioxidant therapy, alone or in combination with corticosteroids, does not improve 6-month survival in severe alcoholic hepatitis.