Journal of hepatology
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Journal of hepatology · Aug 2010
Clinical, biochemical, and pathological characteristics of clevudine-associated myopathy.
The aim of this study was to define the clinical, biochemical, and pathological characteristics of myopathy developed during clevudine therapy. ⋯ Myopathy associated with clevudine is characterized by a weakness in proximal muscles of the lower extremities with elevated muscle enzymes and presumably caused by mitochondrial toxicities. Careful medical and serologic examinations are essential for the early detection and management of this potential adverse reaction in CHB patients under clevudine therapy.
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Journal of hepatology · Aug 2010
Comparative StudyThe 148M allele of the PNPLA3 gene is associated with indices of liver damage early in life.
Childhood obesity is a growing problem worldwide. Non-alcoholic fatty liver disease (NAFLD) is frequently associated with obesity in children. Recently, the PNPLA3 gene I148M (rs738409) variant was demonstrated to be strongly associated with hepatic steatosis in obese adults. In this study we add further insight into the role of PNPLA3 by exploring whether this association begins early in life in obese children or becomes manifest only in adulthood. ⋯ Our data show that the PNPLA3 gene I148M variant is associated with increased levels of ALT/AST in obese children and adolescents, suggesting that it confers genetic susceptibility to liver damage from a young age.