Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine
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Fluid-attenuated inversion recovery (FLAIR) is a routinely used technique in clinical practice to detect long T(2) lesions by suppressing the cerebrospinal fluid. Concerns remain, however, that the inversion pulse in FLAIR imparts T(1) weighting that can decrease the detectability and mischaracterize some lesions. Hence, FLAIR is usually acquired in conjunction with a standard T(2) to guard against these concerns. ⋯ T(1) -nulled DIR provides equivalent or superior contrast between gray and white matters as well as white matter and multiple sclerosis lesion at the same repetition time. Multiple sclerosis lesions appeared sharper on T(1) -nulled DIR compared to FLAIR. T(1) -nulled DIR has the potential to replace the combination of standard T(2) and FLAIR acquisitions in many clinical protocols.