Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine
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To develop a methodological framework to simultaneously measure R 2 * and magnetic susceptibility in trabecularized yellow bone marrow and to investigate the sensitivity of Quantitative Susceptibility Mapping (QSM) for measuring trabecular bone density using a non-UTE multi-gradient echo sequence. ⋯ A method for multi-paramteric mapping, including R 2 * -mapping and QSM was developed for measuring trabecularized yellow bone marrow, showing good sensitivity of QSM for measuring trabecular bone density.
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Quantitative susceptibility mapping (QSM) provides information about tissue composition and organization. However, current acquisition methods can be quite time consuming, limiting the use of QSM in studies and in monitoring dynamic events. In this work, time efficient spiral acquisitions are combined with a model-based image reconstruction approach. Magnetic field inhomogeneity artifacts are corrected to obtain full brain susceptibility maps. ⋯ Susceptibility maps obtained with the spiral acquisition and the model-based reconstruction agree with the ones obtained with the spin-warp gradient echo acquisition. Using the 3D spiral acquisition, full brain susceptibility maps at the resolution of 1 mm isotropic are obtained in 23 s CONCLUSIONS: Image distortions and blurring due to magnetic field inhomogeneity are removed while maintaining tissue magnetic susceptibility information, resulting in QSM maps in much shorter acquisition time.