Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine
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To improve the accuracy of quantitative susceptibility mapping plus quantitative blood oxygen level-dependent magnitude (QSM+qBOLD or QQ) based mapping of oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2 ) using temporal clustering, tissue composition, and total variation (CCTV). ⋯ The CCTV mapping significantly improves the robustness of QQ-based OEF against noise.