Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine
-
Chemical shift based methods are often used to achieve uniform water-fat separation that is insensitive to Bo inhomogeneities. Many spin-echo (SE) or fast SE (FSE) approaches acquire three echoes shifted symmetrically about the SE, creating time-dependent phase shifts caused by water-fat chemical shift. This work demonstrates that symmetrically acquired echoes cause artifacts that degrade image quality. ⋯ Theoretical calculations predict that the optimal echo combination occurs when the relative phase of the echoes is separated by 2pi/3, with the middle echo centered at pi/2+pik (k=any integer), i.e., (-pi/6+pik, pi/2+pik, 7pi/6+pik). Only with these echo combinations can noise performance reach the maximum possible and be independent of the proportion of water and fat. Close agreement between theoretical and experimental results obtained from an oil-water phantom was observed, demonstrating that the iterative least-squares decomposition method is an efficient estimator.
-
Multipoint water-fat separation methods have received renewed interest because they provide uniform separation of water and fat despite the presence of B0 and B1 field inhomogeneities. Unfortunately, full-resolution reconstruction of partial k-space acquisitions has been incompatible with these methods. Conventional homodyne reconstruction and related algorithms are commonly used to reconstruct partial k-space data sets by exploiting the Hermitian symmetry of k-space in order to maximize the spatial resolution of the image. ⋯ The phase information of complex source images used in a water-fat separation acquisition is necessary to decompose water from fat. In this work, homodyne imaging is combined with the IDEAL (iterative decomposition of water and fat with echo asymmetry and least squares estimation) method to reconstruct full resolution water and fat images free of blurring. This method is extended to multicoil steady-state free precession and fast spin-echo applications and examples are shown.
-
Quantification of dynamic contrast-enhanced (DCE) MRI based on pharmacokinetic modeling requires specification of the arterial input function (AIF). A full representation of the plasma concentration data, including the initial rise and decay parts, considering the delay and dispersion of the bolus contrast is important. This work deals with modeling of DCE-MRI data from the knees of children with a history of juvenile rheumatoid arthritis (JRA) by using an AIF extracted from the signal enhancement data from the nearby popliteal artery. ⋯ The pharmacokinetic parameters (mean+/-SD) derived from AIF1, using the average plasma concentration data, were as follows: SNVM Ktrans'(min-1)=0.52+/-0.34, kep(min-1)=0.71+/-0.39, and V'p=0.33+/-0.16, and for the distal femoral physis (DFP) Ktrans'(min-1)=1.83+/-1.78, kep(min-1)=2.65+/-1.80, and V'p=0.46+/-0.31. The pharmacokinetic parameters in the SNVM may be useful for investigating activity and therapeutic efficacy in studies of JRA. Longitudinal studies are necessary to find or demonstrate the parameter that is more sensitive to disease activity.
-
A new magnetization preparation and image acquisition scheme was developed to obtain high-resolution brain images with optimal tissue contrast. The pulse sequence was derived from an optimization process using simulated annealing, without prior assumptions with regard to the number of radiofrequency (RF) pulses and flip angles. The resulting scheme combined two inversion pulses with the acquisition of three images with varying contrast. ⋯ The use of three-dimensional (3D) sensitivity-encoded (SENSE) echo-planar imaging (EPI) for image acquisition made it possible to achieve a 1.15(3) mm3 isotropic resolution within a scan time of 10 min 21 s. The cortical GM signal-to-noise ratio (SNR) in the calculated GM-only image varied between 30 and 100. The novel technique was evaluated in combination with blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) on human subjects, and provided for excellent coregistration of anatomical and functional data.
-
Comparative Study
Analysis and compensation of eddy currents in balanced SSFP.
Balanced steady-state free precession (SSFP) completely compensates for all gradients within each repetition time (TR), and is thus very sensitive to any magnetic field imperfection that disturbs the perfectly balanced acquisition scheme. It is demonstrated that balanced SSFP is especially sensitive to changing eddy currents that are induced by stepwise changing phase-encoding (PE) gradients. In contrast to the linear k-space trajectory, which has small variations between consecutive encoding steps, other encoding schemes (e.g., centric, random, or segmented orderings) exhibit significant jumps in k-space between adjacent PE steps, and consequently induce rapidly changing eddy currents. ⋯ A generic (and thus system-unrelated) compensation strategy is proposed that consists of "pairing" of consecutive PE steps. Another approach is based on partial dephasing along the slice direction that annihilates eddy-current-induced signal oscillations. Both pairing of the PE steps and "through-slice equilibration" are easy to implement and allow the use of arbitrary k-space trajectories for balanced SSFP.