Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine
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An increasing number of studies show that magnetic susceptibility in white matter fibers is anisotropic and may be described by a tensor. However, the limited head rotation possible for in vivo human studies leads to an ill-conditioned inverse problem in susceptibility tensor imaging (STI). Here we suggest the combined use of limiting the susceptibility anisotropy to white matter and imposing morphology constraints on the mean magnetic susceptibility (MMS) for regularizing the STI inverse problem. ⋯ The proposed regularization strategy for STI can improve estimation of the susceptibility tensor in white matter.
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To develop a fast and flexible free-breathing dynamic volumetric MRI technique, iterative Golden-angle RAdial Sparse Parallel MRI (iGRASP), that combines compressed sensing, parallel imaging, and golden-angle radial sampling. ⋯ The high performance and flexibility provided by iGRASP can improve clinical studies that require robustness to motion and simultaneous high spatial and temporal resolution. Magn Reson Med 72:707-717, 2014. © 2013 Wiley Periodicals, Inc.
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To introduce a new k-space traversal strategy for segmented three-dimensional echo planar imaging (3D EPI) that encodes two partitions per radiofrequency excitation, effectively reducing the number excitations used to acquire a 3D EPI dataset by half. ⋯ 3D RE-EPI resulted in significant increases in temporal resolution for whole brain acquisitions and in improved physiological noise characterization compared with 2D-EPI and segmented 3D EPI.
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To propose a susceptibility map-weighted imaging (SMWI) method by combining a magnitude image with a quantitative susceptibility mapping (QSM) -based weighting factor thereby providing an alternative contrast compared with magnitude image, susceptibility-weighted imaging, and QSM. ⋯ SMWI presents an alternative contrast for susceptibility-based imaging. The validity of this method was demonstrated using in vivo data. This proposed method together with denoising allows high-quality reconstruction of susceptibility-weighted image of human brain in vivo.
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Small-tip fast recovery (STFR) imaging is a recently proposed steady-state sequence that has similar image contrast as balanced steady-state free precession but has the potential to simultaneously remove banding artifacts and transient fluctuation. STFR relies on a "tip-up" radiofrequency (RF) pulse tailored to the accumulated phase during the free precession (data acquisition) interval, designed to bring spins back to the longitudinal axis, thereby preserving transverse magnetization as longitudinal magnetization for the next pulse repetition time. We recently proposed an RF-spoiled STFR sequence suitable for thin slab imaging, however, in many applications, e.g., functional magnetic resonance imaging or isotropic-resolution structural imaging, three-dimensional (3D) steady-state imaging is desirable. Unfortunately, 3D STFR imaging is challenging due to the need for 3D tailored RF pulses. Here, we propose new strategies for improved 3D STFR imaging, based on (i) unspoiled imaging, and (ii) joint design of nonslice-selective tip-down/tip-up RF pulses. ⋯ Using the proposed unspoiled sequence and joint RF pulse design, STFR brain images in a 3D region of interest with balanced steady-state free precession-like signal properties but with reduced banding can be obtained.