Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society
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J Clin Neurophysiol · Feb 2007
Controlled Clinical TrialIntraoperative risk of seizures associated with transient direct cortical stimulation in patients with symptomatic epilepsy.
Direct cortical stimulation--either with the 60-Hz stimulation or the train-of-five technique--is commonly agreed on being the gold standard for intraoperative mapping of the motor cortex and the motor pathways but may result in an intraoperative seizure. The occurrence of intraoperative stimulation associated seizures with respect to symptomatic epilepsy was evaluated in a group of 129 patients undergoing tumor resection within the central region. Data were reviewed with respect to the frequency of seizures with both stimulation techniques and symptomatic epilepsy. ⋯ In 1 of 63 patients (1.6%) presenting with symptomatic epilepsy, a stimulation-associated seizure occurred, and 1 of the other 66 patients (1.5%) had a seizure (n.s., not significant). In the literature, stimulation associated seizures are reported in 1.2% with the train-of-five technique and significantly more frequently in 9.5% with the 60-Hz technique (P < 0.001). In summary, there is no increased risk of the occurrence of stimulation-associated seizures during surgery for patients with symptomatic epilepsy compared with those patients without.
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J Clin Neurophysiol · Feb 2007
Central processing of acute muscle pain in chronic low back pain patients: an EEG mapping study.
The presence of perceptual sensitization and related brain responses was examined in 14 chronic low back pain (CLBP) patients and 13 healthy controls comparable in age and sex. Multichannel EEG recordings and pain ratings were obtained during the presentation of 800 painful electrical intramuscular and intracutaneous stimuli each to the left m. erector spinae and the left m. extensor digitorum. Perception and pain thresholds were not significantly different between the two groups, though patients showed significantly more perceptual sensitization. ⋯ These results indicate enhanced perceptual sensitization and enhanced processing of the sensory-discriminative aspect of pain, as expressed in the N80 component, in CLBP patients. This may be one neurophysiologic basis of sensitization and the chronicity process. The lower P260 component in the patients may be explained in terms of tonic pain inhibiting phasic pain or may be related to the affective distress observed in this patient group.