Current opinion in gastroenterology
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Curr. Opin. Gastroenterol. · Nov 2001
Nonsteroidal anti-inflammatory drug gastrointestinal toxicity.
Toxic effects in the upper gastrointestinal tract, primarily complicated gastric and intestinal ulcers, are the most common undesirable effects of the nonsteroidal anti-inflammatory drugs. During the last several years, there have been several advances, both in the laboratory and clinically, toward reducing nonsteroidal anti-inflammatory drugs' gastrointestinal toxicity. ⋯ Many of these advances have occurred during the last year. This review focuses on several of the important recent observations that have improved understanding and safety of nonsteroidal anti-inflammatory drugs in the gastrointestinal tract.