Current opinion in gastroenterology
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Curr. Opin. Gastroenterol. · Nov 2016
ReviewUpdate on innate immunity and perspectives on metabolite regulation in acute pancreatitis.
Acute pancreatitis is a major cause of gastrointestinal morbidity for which specific therapy is greatly needed to prevent progression to and induce resolution of severe disease. ⋯ Targeting innate immune cell populations and metabolite signaling pathways in acute pancreatitis may result in broader and ultimately more efficacious re-direction of the inflammatory programme toward disease resolution and improved clinical outcomes.