Current opinion in gastroenterology
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Curr. Opin. Gastroenterol. · Mar 2016
ReviewFrom coeliac disease to noncoeliac gluten sensitivity; should everyone be gluten free?
Gluten-free diets (GFDs) have seen a disproportional rise in use and popularity relative to the prevalence of established gluten-related disorders such as coeliac disease or immunoglobulin E wheat allergy. This entity has been termed noncoeliac gluten sensitivity (NCGS). This review aims to provide a current perspective on the emerging evidence for and against NCGS, along with the associated need for a GFD. ⋯ Despite the rising use of a GFD further studies are required to clearly establish the extent and exclusivity of gluten in NCGS.
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There is an increasing realization that the microorganisms which reside within our gut form part of a complex multidirectional communication network with the brain known as the microbiome-gut-brain axis. In this review, we focus on recent findings which support a role for this axis in modulating neurodevelopment and behavior. ⋯ Understanding the mechanisms by which the bacterial commensals of our gut are involved in brain function may lead to the development of novel microbiome-based therapies for these mood and behavioral disorders.