The Clinical journal of pain
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To investigate whether comorbid major depressive disorder (MDD) influenced the efficacy and safety of duloxetine in treating fibromyalgia (FM). ⋯ Duloxetine was effective in reducing pain and other symptoms in FM patients with and without MDD and demonstrated a similar safety profile for both groups.
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To summarize the available evidence on the use of anticonvulsant drugs for the treatment of various conditions of neuropathic pain. ⋯ Gaps in the evidence are striking. Recommendations directly supported by the evidence by drug and by condition are made.
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Randomized Controlled Trial Clinical Trial
Efficacy of microcurrent therapy in the treatment of chronic nonspecific back pain: a pilot study.
Microcurrent therapy (MCT) is a novel treatment for pain syndromes. The MCT patch is hypothesized to produce stimuli that promote tissue healing by facilitating physiologic currents. Solid evidence from randomized clinical trials is lacking. To evaluate the efficacy of MCT in treating aspecific, chronic low-back pain, we conducted a double-blind, randomized, crossover, pilot trial. ⋯ A positive trend in MCT use for aspecific, chronic low-back pain is reported. Further investigations are required to evaluate the significance and relevance of this.
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Physiotherapy is considered an important treatment option in patients with upper limb complex regional pain syndrome type-1 (CRPS-1). In case of chronic CRPS-1, exercise therapy of the affected limb forms an important part of the physiotherapeutic program. We investigated whether muscle loading in chronic CRPS-1 patients is associated with impairments in muscle circulation of the forearm of the affected limb. ⋯ Muscle loading does not seems to be related to impairments in muscle oxygen uptake in forearm muscles of upper limbs affected by chronic CRPS-1. Our results suggest that exercise therapy can be safely used in physiotherapeutic training programs for chronic CRPS-1 of the upper limb.
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Randomized Controlled Trial
A randomized controlled trial of vapocoolant for pediatric immunization distress relief.
The purpose of this study was to evaluate the effectiveness of vapocoolant for preschoolers' immunization injection pain relief. ⋯ This study revealed that vapocoolant is not an effective pain management intervention for children's intramuscular injections.