The Clinical journal of pain
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Randomized Controlled Trial
Mindfulness-based Intervention does not Influence Cardiac Autonomic Control or Pattern of Physical Activity in Fibromyalgia During Daily Life: An Ambulatory, Multi-measure Randomized Controlled Trial.
Fibromyalgia (FM) is a syndrome characterized by severe pain, fatigue and sleep disturbance. There is evidence of central hyper-responsiveness to sensory stimulation and impaired cardiovascular autonomic control. Laboratory investigations suggest that mindfulness-based stress reduction (MBSR) may improve autonomic functioning in FM. However, these findings may not reflect what occurs during naturalistic conditions, and MBSR studies during real-life functioning are lacking. We conducted a randomized controlled, 3-armed study with 168 female FM patients. This report describes cardiac, respiratory, and physical activity findings. ⋯ MBSR did not produce cardiac autonomic benefits or changes in daily activity in FM. Furthermore, the lack of an association between patient-experienced clinical improvement and objective physiological measures suggests that subjective changes in the wellbeing of FM patients over time are not related to alterations in the cardiorespiratory autonomic function or activity levels.
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Randomized Controlled Trial Comparative Study
Preoperative but Not Postoperative Flurbiprofen Axetil Alleviates Remifentanil Induced Hyperalgesia after Laparoscopic Gynecological Surgery: A Prospective, Randomized, Double-blinded, Trial.
Acute remifentanil exposure during intraoperative analgesia might enhance sensitivity to noxious stimuli and nociceptive responses to innocuous irritation. Cyclooxygenase inhibition was demonstrated to attenuate experimental remifentanil-induced hyperalgesia (RIH) in rodents and human volunteers. The study aimed to compare the effects of preoperative and postoperative flurbiprofen axetil (FA) on RIH after surgery. ⋯ Preoperative FA reduces postoperative RIH in patients undergoing laparoscopic gynecologic surgery under sevoflurane-remifentanil anesthesia.
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Randomized Controlled Trial Multicenter Study
Sebacoyl Dinalbuphine Ester Extended-Release Injection for Long- Acting Analgesia: A Multicenter, Randomized, Double Blind, And Placebo-controlled study in Hemorrhoidectomy Patients.
This study was conducted to evaluate the safety and efficacy of single sebacoyl dinalbuphine ester (SDE) injection (150 mg/2 mL) when administered intramuscularly to patients who underwent hemorrhoidectomy for postoperative long-acting analgesia. ⋯ SDE injection demonstrated an extended analgesia effect, with a statistically significant reduction in pain intensity through 48 hours and 7 days after hemorrhoidectomy.