The Clinical journal of pain
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It has been reported that the optimal concentration of epidural dexmedetomidine for labor analgesia is 0.5 μg/mL when combined with 0.1% ropivacaine. This study investigated the median effective concentration (EC50) of epidural ropivacaine for labor analgesia when combined with 0.5 μg/mL dexmedetomidine. ⋯ The EC50 of epidural ropivacaine for labor analgesia was 0.083% (95% CI, 0.077%-0.089%) and decreased to 0.062% (95% CI, 0.058%-0.066%) when combined with 0.5 μg/mL dexmedetomidine (http://www.chictr.org.cn, registration number: ChiCTR-OPC-16008548).
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This study examined the pattern of use and factors predicting prolonged prescription opioid medications among cancer patients following treatment with curative intent. ⋯ Treatment with chemotherapy, pain-modifying medications, cancer stage, and interval between diagnosis and treatment are the best predictors for continuous opioid use. The current epidemic of opioid misuse and abuse makes examination current practices and identifification of areas of improvement imperative.
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Low back pain (LBP) is frequent and burdensome among police officers, but occupational and ergonomic factors associated with LBP and its chronic symptoms have never been studied among these workers using a biopsychosocial model. This study aimed at exploring such factors associated with acute or subacute LBP and chronic low back pain (CLBP) among car-patrol police officers. ⋯ Few occupational and ergonomic factors that police organizations could use to better tailor prevention were found to be associated with acute or subacute LBP and CLBP. This cross-sectional study is an efficient first investigation for screening hypotheses that should be confirmed in further cohort studies.
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Randomized Controlled Trial Multicenter Study
Efficacy and Safety of Intravenous Meloxicam in Patients With Moderate-to-Severe Pain Following Bunionectomy: A Randomized, Double-Blind, Placebo-controlled Trial.
To evaluate the analgesic efficacy and safety of a novel intravenous (IV) formulation of meloxicam (30 mg) in patients with moderate-to-severe pain following a standardized, unilateral bunionectomy with first metatarsal osteotomy and internal fixation. ⋯ Meloxicam IV doses of 30 mg provided effective pain relief when administered once daily by bolus injection to patients with moderate-to-severe pain following bunionectomy, and had an acceptable safety profile.
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It is important to identify aspects of analgesic use that are associated with harm in chronic pain. Historically, the focus has been patterns of use (eg, overuse). This study evaluated another aspect of use-rather than evaluating how analgesics were being used, the primary interest was in why they were being used. ⋯ Results support the utility of examining reasons for analgesic use; use to achieve emotional modulation/sedation may be particularly associated with risk. The data also provide support for the questionnaire developed, the Reasons for Analgesic Use Measure.