The Clinical journal of pain
-
To systematically identify and critically assess clinical trials that use enriched enrollment randomized withdrawal (EERW) trial design as a methodology for assessing the effect of analgesics pain. ⋯ EERW trials are an emerging type of study design that in certain settings may offer advantages over traditional trial designs in characterizing the effects of analgesic medications.
-
Randomized Controlled Trial
A randomized controlled trial of the ShotBlocker for children's immunization distress.
Vaccinations protect children against deadly diseases and approximately 30 immunizations are recommended for children by 6 years of age. However, immunization injections cause negative short-term and long-term consequences for children. The Gate Control Theory of pain suggests that physical interventions (eg, rubbing the site) may be helpful, but they are not well validated for children's acute pain. This randomized trial examined the effectiveness of the ShotBlocker, a physical intervention designed to decrease children's injection pain. ⋯ The data do not support the effectiveness of the ShotBlocker for acute pediatric pain relief. Clinical and theoretical implications are discussed.
-
Randomized Controlled Trial Comparative Study
A comparison of migraine patients with and without allodynic symptoms.
Although the association of symptoms of allodynia with migraine have been reported, there is a paucity of studies on Asians. ⋯ Allodynic symptoms occurred in 57.1% patients with migraine. In allodynic patients with moderate-to-severe headache, rizatriptan resulted in greater pain relief compared with ibuprofen. These results need further confirmation in larger study.
-
Determine the impact of co-occurring chronic pain and obesity on health-related quality of life (HRQOL) in children and adolescents. ⋯ Co-occurring chronic pain and obesity exacerbates the impact of chronic pain alone on the HRQOL of children and adolescents. Routinely screening pediatric patients with chronic pain for elevated body mass index is recommended.