The Clinical journal of pain
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Comparative Study
Personality factors in the explanation of sex differences in pain catastrophizing and response to experimental pain.
To examine the effects of personality and pain catastrophizing upon pain tolerance and pain ratings and to examine the impact of an experimental pain induction on subsequent ratings of catastrophizing. ⋯ The results suggest that sex differences in catastrophizing and pain responsivity are partially accounted for by the dispositional tendency to describe oneself as emotionally vulnerable. The findings also suggest that pain catastrophizing may be situational as well as dispositional.
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The objective of this study is to determine the effect of oral ketamine on pain and allodynia associated with multiple sclerosis. A 60-year-old woman with multiple sclerosis was referred to our clinic because of severe pain and allodynia. Oral ketamine was started at a dose of 20 mg once a day and increased to twice a day. Oral ketamine was effective in the treatment of the pain and allodynia associated with multiple sclerosis.
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The objective of this study is to investigate sympathetic nervous system involvement in 2 patients with painful legs and moving toes. The first case was studied several years after the initiating trauma produced a peripheral nerve lesion and demonstrated the characteristic sequence of progression of pain and moving toes from the injured leg to the contralateral leg. The second case was initially studied within 3 months of an injury that did not produce definitive signs of a peripheral nerve lesion. ⋯ These symptoms and signs disappeared after lumbar sympathectomy, and re-emerged when signs of sympathetic reinnervation were detected. We concluded that sympathetic neuronal discharge may provoke pain by activating an impulse generator in the affected limb. Sympathetic involvement in the painful legs and moving toes syndrome appeared to be greater in the second case than the first, presumably due to differences in the initial injury or stage of the condition.
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Review
Complementary and alternative approaches to the treatment of persistent musculoskeletal pain.
To review common complementary and alternative treatment modalities for the treatment of persistent musculoskeletal pain in older adults. ⋯ While the use of complementary and alternative modalities for the treatment of persistent musculoskeletal pain continues to increase, rigorous clinical trials examining their efficacy are needed before definitive recommendations regarding the application of these modalities can be made.
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Randomized Controlled Trial Comparative Study Clinical Trial
Double-blind parallel comparison of multiple doses of apraclonidine, clonidine, and placebo administered intra-articularly to patients undergoing arthroscopic knee surgery.
This clinical study assessed and compared the potential analgesic and adverse effect of IA apraclonidine with IA clonidine. ⋯ The IA application of 150 microg apraclonidine and 150 microg clonidine provide similar degree of postoperative analgesia following knee arthroscopic surgery without any difference in adverse events.