European journal of epidemiology
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The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, otolaryngological, locomotor, and respiratory diseases. ⋯ This article gives the rationale of the study and its design. It also presents a summary of the major findings and an update of the objectives and methods.