Diabetes research and clinical practice
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Diabetes Res. Clin. Pract. · Dec 2015
Meta AnalysisIncretin-based therapies are associated with acute pancreatitis: Meta-analysis of large randomized controlled trials.
Previous studies have offered weak and conflicting evidence regarding the impact of incretin-based oral antihyperglycemic agents on risk of acute pancreatitis. This meta-analysis of three recent mega-trials found an 82% increase in the odds of acute pancreatitis with the use of these agents compared to usual care (95% CI, 1.17-2.82).