Diabetes research and clinical practice
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Diabetes Res. Clin. Pract. · Apr 2016
Neuroprotective effects of chronic administration of levetiracetam in a rat model of diabetic neuropathy.
Diabetic neuropathy (DNP) is a frequent and serious complication of diabetes mellitus (DM) that leads to progressive and length-dependent loss of peripheral nerve axons. The purpose of the present study is to assess the neuroprotective effects of levetiracetam (LEV) on DNP in a streptozotocin (STZ)-induced DM model in rats. ⋯ The results of the present study suggest that LEV may have therapeutic effects in DNP through modulation of anti-oxidant and anti-apoptotic pathways.