Diabetes research and clinical practice
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Diabetes Res. Clin. Pract. · Dec 2007
Recombinant human epidermal growth factor (REGEN-D 150): effect on healing of diabetic foot ulcers.
Recombinant human epidermal growth factor (REGEN-D 150), which was cloned and over expressed in E. coli, has shown enhanced healing of chronic diabetic foot ulcers (DFU) by significantly reducing the duration of healing in addition to providing excellent quality of wound healing and reepithelization. Post-marketing surveillance (PMS) study of REGEN-D 150 in 135 patients of DFU in India was compared with Phase III clinical trial data of REGEN-D 150 in India. Statistical analysis of study data determined that the empirical survival probability distribution, in terms of non-healing of ulcers, was lowest in the case of PMS study, better than that for Phase III; more DFU patients were healed in PMS study. ⋯ The average wound healing time was significantly lower in PMS study, 4.8 weeks, while it was 9 weeks in Phase III clinical trials while the average wound healing with REGEN-D 150 was found to be 86% in this study. REGEN-D 150 has been found to result in healthy granulation and stimulate epithelization, thus leading to final wound closure. The PMS study has established the efficacy of REGEN-D 150 in faster healing of diabetic foot ulcers.
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Diabetes Res. Clin. Pract. · Dec 2007
Clinical outcomes associated with the use of subcutaneous insulin-by-glucose sliding scales to manage hyperglycemia in hospitalized patients with pneumonia.
Despite its ubiquitous use, the value of subcutaneous insulin-by-glucose sliding scales (SISS) for the management of in-patient hyperglycemia has not been carefully assessed. ⋯ Among patients admitted to a medical ward with pneumonia, an SISS is associated with higher glucose levels and poorer clinical outcomes.
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Diabetes Res. Clin. Pract. · Nov 2007
Diabetes team consultation: impact on length of stay of diabetic patients admitted to a short-stay unit.
To assess the impact of endocrinology team consultation on hospital stay and clinical outcomes of diabetic patients admitted with a primary non-diabetes-related diagnosis in a short stay unit (SSU). ⋯ The intervention of a diabetes team diminished the average length of stay of diabetic patients.
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Diabetes Res. Clin. Pract. · Sep 2007
Educational program for diabetic patients in Korea--multidisplinary intensive management.
The socioeconomic burden of type 2 diabetes and its complications has become a big social issue in Korea. And so, the proper management of diabetes in terms of its prevention and management of complications are considered the most important tasks in our healthcare system and these can be accomplished through the multidisciplinary program. Our program is composed of separate educational programs for in-patients and out-patients, individualized teaching, and group teaching. ⋯ As for the healthcare providers, physicians are able to treat their patients more efficiently. Thus, both the patient and the healthcare centers can benefit from this multidisciplinary educational program. Diabetes educational program should be a basis for the management of diabetes.
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Diabetes Res. Clin. Pract. · Aug 2007
Randomized Controlled TrialGlyceryl trinitrate spray in the management of painful diabetic neuropathy: a randomized double blind placebo controlled cross-over study.
Various drugs are effective in the management of painful diabetic neuropathy, but none is completely satisfactory. The objective of this study is to test the effectiveness and safety aspect of glyceryl trinitrate (GTN) in the management of painful diabetic neuropathy as a nitric oxide (NO) donor with local vasodilating properties in spray form. ⋯ GTN spray, a well tolerated drug, provides significant improvement in painful diabetic neuropathy. These data provide a basis for future trials for longer duration in a larger group of patients.