Diabetes research and clinical practice
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Diabetes Res. Clin. Pract. · Jun 2006
Multicenter StudyDetection of ketonemia and its relationship with hyperglycemia in type 1 diabetic patients.
The aims of this study were to assess the prevalence of ketosis in type 1 diabetic patients with casual hyperglycemia (>250 mg/dl), to establish the relationship between glycemia and ketonemia during daily life, and to determine the utility of ketonemia. Capillary glycemia levels from 562 type 1 diabetic patients were recorded. Prevalence of casual hyperglycemia was 27.58%, and prevalence of asymptomatic ketonemia was 8.39%. ⋯ That is in 20 patients with positive ketonuria, ketonemia was not detected, probably because ketosis was already resolved. Asymptomatic ketosis was observed in the hyperglycemic type 1 diabetic population, and metabolic control of these patients with a point of care device is recommended, together with a subsequent revision of insulin treatment. Furthermore, this study supports the opinion that the presence of ketosis, detected by beta-OHB levels, even below levels considered as pathologic, together with hyperglycemia, must be taken into account for proper monitoring and therapeutic control of diabetic patients.
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Diabetes Res. Clin. Pract. · Dec 2005
Prevalence and control of dyslipidemia among persons with diabetes in the United States.
We assessed the prevalence, treatment, and control of dyslipidemia among United States (U.S.) adults with diabetes. ⋯ Many persons with diabetes remain uncontrolled for dyslipidemia. Intensified efforts at screening and treatment according to current guidelines are warranted.
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Diabetes Res. Clin. Pract. · Nov 2005
Review Case ReportsDiabetic lipemia with eruptive xanthomatosis in a lean young female with apolipoprotein E4/4.
Eruptive xanthomas in adults are usually indicative of chylomicronemia. Although diabetes mellitus is the most common secondary cause of chylomicronemia, which is designated as diabetic lipemia, the clinical characteristics of diabetes with regard to development of xanthomas are not well defined. In this paper, we describe a young female who displayed eruptive xanthomas as an initial manifestation of diabetic lipemia. ⋯ The apolipoprotein E phenotype was E4/4, which is known to be associated with type V hyperlipoproteinemia. Hypoadiponectinemia of 1.7 microg/ml was also revealed, which may, in part, account for the insulin resistance and decreased LPL activity. In conclusion, the clustering of apolipoprotein E4/4 and hypoadiponectinemia, in addition to insulin resistance and poor glycemic control, might have resulted in hypertriglyceridemia with eruptive xanthomatosis in this subject.
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Diabetes Res. Clin. Pract. · Oct 2005
Hypertension in type 2 diabetes mellitus in Isfahan, Iran: incidence and risk factors.
Evidence on the long-term incidence of and risk factors of hypertension in diabetic patients is scarce and mainly derived from studies in developed countries. Evidence from developing countries is required for planning a well-co-ordinated approach to this public health problem in these countries. ⋯ These findings will help the identification of those patients at particular risk of hypertension and strongly support the case for vigorous control of blood pressure on type 2 diabetic patients.
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Diabetes Res. Clin. Pract. · Mar 2005
Multicenter StudyPast 10-year status of insulin therapy for preschool-age Japanese children with type 1 diabetes.
The aim of this study was to evaluate the past 10-year status of insulin therapy for preschool-age children with type 1 diabetes in Japan. One-hundred and forty-two patients who had been diagnosed at less than 5 years of age within the past 10 years (1993-2002) at 36 hospitals were registered in this study on April 2003. The methods of daily insulin therapy and episodes of severe hypoglycemia during the preschool period were investigated. ⋯ Most parents worried about the glycosylated hemoglobin value at each hospital visit. They were next very afraid of nocturnal severe hypoglycemia, independent of any actual experience. These results suggest that although insulin therapy can involve various methods, the important point is to simultaneously provide good glycemic control and prevent severe hypoglycemia, especially during this age.