The Canadian journal of cardiology
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Therapeutic hypothermia preserves neurologic function in post-cardiac arrest patients. Several studies suggest that hypothermia may preserve myocardial function in patients with acute myocardial infarction (AMI). We carried out a systematic review to evaluate the efficacy of therapeutic hypothermia at reducing infarct size and decreasing major adverse cardiac events (MACEs) and all-cause mortality in AMI patients. ⋯ Subgroup analyses suggested that hypothermia may reduce infarct size in patients with anterior wall infarction. Our review suggests that therapeutic hypothermia is safe and feasible. However, more evidence is needed to determine whether therapeutic hypothermia is associated with improved infarct size, MACEs, or all-cause mortality in RCTs of AMI patients.