The Canadian journal of cardiology
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To determine the time course of free radical generation and the role of allopurinol as a cardioprotective agent during coronary artery bypass surgery. ⋯ The results of this study show that, during bypass surgery, there is an increase in lipid peroxidation products and cardiac creatine kinase enzyme at the onset of reperfusion indicating increased free radical activity. It also suggests that pretreatment with allopurinol could effectively attenuate post-ischemic reperfusion injury.
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To review the major changes and advances in cardiopulmonary resuscitation (CPR) since its first description over 100 years ago. ⋯ CPR has become increasingly recognized as an important element in the chain of survival for victims of cardiopulmonary arrest. Several advances in delivery and technique have resulted in improved resuscitation of cardiopulmonary arrest victims. However, despite these advances, additional research is needed to improve further the still dismal overall survival of victims of cardiopulmonary arrest.