The Journal of international medical research
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Comparative Study Clinical Trial Controlled Clinical Trial
Imipramine and rheumatoid factor.
It has been reported that imipramine reduces the titre of rheumatoid factor in schizophrenic patients. Twenty out-patients suffering from classical rheumatoid arthritis and having rheumatoid factor titre equal to, or greater than 1:64, were treated in a double-blind trial with imipramine 75 mg or matching placebo. In this study the dose of imipramine used failed to affect the levels of rheumatoid factor.