The Journal of international medical research
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Randomized Controlled Trial
The effect of extraction angle on endotracheal tube extubation force: Simulation and randomized clinical trial.
To evaluate the extraction force generated at different extubation angles using a manikin simulation and a randomized clinical trial. ⋯ Findings in a manikin simulation were confirmed by those of a randomized clinical trial, where extubation at 60° required less force than 90°, and was accompanied by less SBP elevation. Extubation at 60° is less invasive than extubation at 90°.
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Meta Analysis Comparative Study
Comparison of early recovery and cognitive function after desflurane and sevoflurane anaesthesia in elderly patients: A meta-analysis of randomized controlled trials.
A meta-analysis to compare postoperative cognitive function and the time to specific recovery events in elderly patients (aged >65 years) anaesthetized with sevoflurane or desflurane. ⋯ Desflurane is associated with a faster recovery from general anaesthesia than sevoflurane in elderly patients.
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To evaluate whether polymorphisms in the gamma-aminobutyric acid A receptor α1 subunit (GABRA1) gene influence sleep induction time, bispectral index score (BIS) during sleep induction and the total dose of midazolam required to reach a Ramsay Sedation Assessment Scale (RSAS) score of 4. ⋯ Polymorphism rs4263535 in GABRA1 intron 4 was associated with deeper sedation by intravenous midazolam. Patients with the A/A rs4263535 genotype required a smaller dose of midazolam.