Journal of cataract and refractive surgery
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J Cataract Refract Surg · May 2003
Effects of topical nonsteroidal antiinflammatory drugs on the expression of matrix metalloproteinases in the cornea.
To assess the effects of nonsteroidal antiinflammatory drug (NSAID) eyedrops on the expression of matrix metalloproteinases in corneal tissue. ⋯ This study provides preliminary evidence that topical application of some NSAIDs can induce the early expression of MMP-1, MMP-2, and MMP-8 in the cornea, suggesting that MMPs play a role in the corneal cytotoxicity of certain NSAIDs.