Clinical endocrinology
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Clinical endocrinology · Mar 2010
Influence of hydrocortisone dosage scheme on health-related quality of life in patients with adrenal insufficiency.
Recent studies suggest that current glucocorticoid replacement therapies fail to completely restore well-being in patients with adrenal insufficiency (AI). ⋯ Health-related QoL was impaired in patients with primary and secondary AI. HC doses above 30 mg/day were associated with a worse health status. Thrice daily intake of HC was not superior to twice daily intake. Our data support the perception that current replacement strategies are still insufficient to fully restore well-being and daily performance.