Clinical endocrinology
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Clinical endocrinology · Jun 2010
Randomized Controlled TrialBenefit of short-term iodide supplementation to antithyroid drug treatment of thyrotoxicosis due to Graves' disease.
Combined treatment with anti-thyroid drugs (ATDs) and potassium iodide (KI) has been used only for severe thyrotoxicosis or as a pretreatment before urgent thyroidectomy in patients with Graves' disease. We compared methimazole (MMI) treatment with MMI + KI treatment in terms of rapid normalization of thyroid hormones during the early phase and examined the later induction of disease remission. ⋯ Combined treatment with MMI and KI improved the short-term control of Graves' hyperthyroidism and was not associated with worsening hyperthyroidism or induction of thionamide resistance.
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Clinical endocrinology · Jun 2010
Clinical TrialHypothalamic-pituitary-adrenal (HPA) axis functioning in relation to body fat distribution.
To relate hypothalamic-pituitary-adrenal (HPA) axis functioning and HPA feedback functioning to body fat distribution in normal weight to obese subjects. ⋯ Disturbance of HPA axis functioning under basal and challenged conditions is related to visceral fat accumulation.