Journal of general internal medicine
-
Randomized Controlled Trial Clinical Trial
Does treatment with L-thyroxine influence health status in middle-aged and older adults with subclinical hypothyroidism?
To determine if health-related quality of life (HRQL) in patients of middle age and older with elevated thyroid-stimulating hormone (TSH) and normal total thyroid hormone levels-subclinical hypothyroidism-improves with L-thyroxine replacement therapy. ⋯ In middle-aged and older patients with elevated TSH and normal T4, it may not be harmful to follow biochemical and clinical status even in the presence of nonspecific symptoms potentially associated with hypothyroidism.