Journal of general internal medicine
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Randomized Controlled Trial Comparative Study
Mood, side-effects and smoking outcomes among persons with and without probable lifetime depression taking varenicline.
Varenicline may be associated with greater mood disturbance and side-effects among smokers with psychiatric history, but empirical evidence is limited. Differential treatment effectiveness by psychiatric history may also exist. ⋯ While some group differences were noted, DH+ smokers did not report qualitatively worse neuropsychiatric symptoms, more new/worsening mood disturbance, or differential abstinence rates compared to DH- smokers.
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Review
Genetic testing before anticoagulation? A systematic review of pharmacogenetic dosing of warfarin.
Genotype-guided initial warfarin dosing may reduce over-anticoagulation and serious bleeding compared to a one-dose-fits-all dosing method. ⋯ We did not find sufficient evidence to support the use of pharmacogenetics to guide warfarin therapy. Additional clinical trials are needed to define the optimal approach to use warfarin pharmacogenetics in clinical practice.
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Multicenter Study Comparative Study
Symptom burden, depression, and spiritual well-being: a comparison of heart failure and advanced cancer patients.
A lower proportion of patients with chronic heart failure receive palliative care compared to patients with advanced cancer. ⋯ Patients with symptomatic heart failure and advanced cancer have similar needs for palliative care as assessed by symptom burden, depression, and spiritual well-being. This implies that heart failure patients, particularly those with more severe heart failure, need the option of palliative care just as cancer patients do.
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Comparative Study
Early identification of co-occurring pain, depression and anxiety.
Depression and anxiety frequently co-occur with pain and may affect treatment outcomes. Early identification of these co-occurring psychiatric conditions during routine pain screening may be critical for optimal treatment. ⋯ VA patients with moderate-severe pain are at high risk for psychological distress, which often goes unrecognized. Providers need to be more vigilant to mental health problems in patients experiencing high pain levels. Targeted screening for co-occurring conditions is warranted.
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Meta Analysis Comparative Study
Tea consumption and risk of type 2 diabetes: a meta-analysis of cohort studies.
Tea consumption has been extensively studied in relation to various diseases, several epidemiologic studies have been performed to investigate the association of tea consumption with type 2 diabetes; however, the results of these studies were not entirely consistent. ⋯ This meta-analysis indicates that tea consumption > or =4 cups per day may lower the risk of type 2 diabetes.