Journal of pain and symptom management
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J Pain Symptom Manage · Mar 2020
Randomized Controlled TrialA Stepped-Wedge Randomized Controlled Trial: Effects of eHealth Interventions for Pain Control among Adults with Cancer in Hospice.
Unrelieved cancer pain at the end of life interferes with achieving patient-centered goals. ⋯ This randomized controlled trial was a negative trial for the primary study outcomes but positive for a secondary outcome. The trial is important for clearly demonstrating the feasibility of implementing the innovative set of interventions.
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J Pain Symptom Manage · Mar 2020
Randomized Controlled TrialControlled-release oxycodone versus placebo in the treatment of chronic breathlessness - a multi-site randomised placebo controlled trial.
Chronic breathlessness is a clinical syndrome that results in significant distress and disability. Morphine can reduce chronic breathlessness when the contributing etiologies are optimally treated. ⋯ There was no signal of benefit from oxycodone over placebo. Future research should focus on investigating the existence of an opioid class effect on the reduction of chronic breathlessness.
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J Pain Symptom Manage · Mar 2020
Randomized Controlled TrialMulti-Symptom Profile Predicts Increased Risk of Poor Outcomes Following Initial Placement of Implantable Cardioverter Defibrillator.
Patients with implantable cardioverter defibrillators (ICDs) are at risk for multiple physical and psychological symptoms. Identification of specific symptom profiles associated with poor outcomes may elucidate novel strategies to enhance symptom management. ⋯ Evaluation of symptom profiles after ICD implantation offers a promising strategy for identifying patients at risk for poor health outcomes.
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J Pain Symptom Manage · Feb 2020
Randomized Controlled TrialA feasibility study to develop and test a cognitive behavioral stress management mobile health application for HIV-related fatigue.
Exacerbated by life stressors, fatigue is the most common symptom for people living with HIV. ⋯ We have proof of concept as to the feasibility, acceptability, and initial signals of efficacy for an mHealth intervention to help people with HIV-related fatigue better cope with stress and reduce their fatigue.
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J Pain Symptom Manage · Feb 2020
Randomized Controlled TrialEarly-Integrated Palliative home care and standard care for end-stage COPD (EPIC): A Phase II pilot RCT testing feasibility, acceptability and effectiveness.
Although early integrated palliative home care (PHC) is believed to be beneficial for patients with chronic obstructive pulmonary disease (COPD), trials testing this hypothesis are rare and show inconclusive results. ⋯ Our intervention on early integrated PHC for end-stage COPD is feasible and accepted but did not yield the anticipated preliminary effectiveness. Before moving to a Phase III trial, enhanced coordination of care, more GP involvement, more intensive training for PHCNs in COPD support, and revision of the trial design, for example, of targeted outcomes in line with individual patient goals and care preferences should be done.