International journal of colorectal disease
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Int J Colorectal Dis · Feb 2008
Review Comparative StudyCapecitabine vs continuous infusion 5-FU in neoadjuvant treatment of rectal cancer. A retrospective review.
Standard therapy for locally advanced rectal cancer (LARC) is concurrent neo-adjuvant chemo-radiation using infusional 5-fluorouracil (CIV-5-FU). Capecitabine (CAP) offers a convenient oral replacement for CIV-5-FU. There is no randomized trial comparing infusional 5-FU to capecitabine. We retrospectively compared the safety and efficacy of CAP-based regimens with well-established CIV-5-FU-based regimens in LARC. ⋯ CAP when compared to CIV seems to have superior efficacy with reasonable toxicities. It is reasonable to treat LARC with CAP + XRT.
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Int J Colorectal Dis · Feb 2008
Comparative StudyComparison of administrative data with the Association of Coloproctology of Great Britain and Ireland (ACPGBI) colorectal cancer database.
This study compared case volume and operative mortality from surgery for colorectal cancer in England derived from Hospital Episode Statistics (HES) with the Association of Coloproctology of Great Britain and Ireland (ACPGBI) colorectal cancer database. ⋯ Overall, agreement between reported caseload and mortality was reasonable at a national, but not hospital, level. Investigation of differences between the two databases at unit level may help to detect under reporting of cases. The combination of data from both sources could be used to develop an enhanced system for monitoring outcomes from colorectal surgery in England.
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Int J Colorectal Dis · Feb 2008
Omentoplasty in rectal cancer surgery prolongs post-operative ileus.
Omentoplasty is frequently used as a safeguard in rectal cancer surgery for wrapping the anastomosis or filling up the pelvic cavity. The omentum is known for its infection defence and haemostatic and angiogenic properties. A disadvantage was hypothesized to be prolonged post-operative ileus, as omentoplasty interrupts the blood flow from an epiploic artery to the stomach. ⋯ A trend for prolonged post-operative ileus was found in patients who underwent an omentoplasty concomitant with their treatment for primary rectal cancer. When assessing the importance of omentoplasty in the future, post-operative ileus should be taken into account.