Journal of gastroenterology and hepatology
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J. Gastroenterol. Hepatol. · Nov 2005
Monitoring and management of antituberculosis drug induced hepatotoxicity.
Hepatotoxicity to antituberculosis therapy (ATT) poses a major challenge. This often results in inadequate therapy. The risk of fulminant hepatic failure and mortality is high once icteric hepatitis develops. There is no consensus on monitoring protocols and for the reintroduction of ATT. ⋯ Periodic laboratory monitoring is important in detecting hepatotoxicity at an early stage, thereby preventing mortality. Sequential reintroduction is often successful.