Journal of gastroenterology and hepatology
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J. Gastroenterol. Hepatol. · Mar 2012
Randomized Controlled Trial Comparative StudyTen-day sequential therapy is more effective than proton pump inhibitor-based therapy in Korea: a prospective, randomized study.
The eradication rate of proton pump inhibitor (PPI)-based triple therapy for Helicobacter pylori (H. pylori) infection has decreased, mainly due to increasing antibiotic resistance, especially against clarithromycin. It has been reported that a 10-day sequential strategy can produce good outcomes. The aim of this prospective study was to assess the efficacy of sequential therapy as the first-line treatment for the eradication of H. pylori in Korea. ⋯ The eradication rate of the 10-day sequential therapy regimen was significantly higher than that of PPI-based triple therapy in the Korean population. Ten-day sequential therapy might be effective as a first-line treatment for H. pylori infection in Korea.