Journal of gastroenterology and hepatology
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J. Gastroenterol. Hepatol. · Mar 2013
Multicenter Study Comparative Study Clinical TrialHistology of symptomatic gastroesophageal reflux disease: is it predictive of response to proton pump inhibitors?
To examine the differences in esophageal histopathology between non-erosive reflux disease (NERD) and reflux esophagitis (RE), and to investigate whether baseline esophageal histopathology can predict the therapeutic response to proton pump inhibitors (PPIs). ⋯ The therapeutic efficacy of PPI can be predicted from the features of biopsied esophageal tissue. Factors predictive of resistance to treatment with PPI are negativity for PGP 9.5 in NERD patients and intraepithelial bleeding in RE patients.