Journal of gastroenterology and hepatology
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J. Gastroenterol. Hepatol. · Aug 2019
Randomized Controlled Trial Comparative StudyComparison of polyp detection during both insertion and withdrawal versus only withdrawal of colonoscopy: A prospective randomized trial.
Polyps seen and not removed during colonoscope insertion are sometimes unable to be found during withdrawal. We aimed to evaluate whether additional inspection and polypectomy during insertion increases adenoma detection rate (ADR) compared with inspection and polypectomy entirely during withdrawal. ⋯ Additional inspection and polypectomy during colonoscope insertion did not improve ADR compared with inspection and polypectomy entirely during withdrawal. These results do not support an additional role for routine inspection during insertion (clinical trial registration number: NCT03444090).
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J. Gastroenterol. Hepatol. · Aug 2019
Meta AnalysisVonoprazan versus proton-pump inhibitors for healing gastroesophageal reflux disease: A systematic review.
Gastroesophageal reflux disease (GERD) is a common disease caused by reflux of gastric contents to the esophagus. Proton-pump inhibitors (PPIs) are recommended as a first-line therapy to treat GERD. Recently, a new potassium-competitive acid blocker, vonoprazan, was launched in Japan. We aimed to evaluate the comparative efficacy of vonoprazan and other PPIs in healing GERD. ⋯ This analysis shows that the GERD healing effect of vonoprazan is higher than that of rabeprazole (20 mg) but not higher than other PPIs. Subgroup analysis indicated that vonoprazan is more effective than most PPIs for patients with severe erosive esophagitis.
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J. Gastroenterol. Hepatol. · Aug 2019
Screening for non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus using transient elastography.
The recommendation in regard to screening for non-alcoholic fatty liver disease (NAFLD) among type 2 diabetes mellitus (T2DM) patients differs in major guidelines. The aim of this paper was to study the prevalence of NALFD and advanced fibrosis among T2DM patients. ⋯ The prevalence of NAFLD and advanced fibrosis based on transient elastography is high among T2DM patients.