Journal of gastroenterology and hepatology
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J. Gastroenterol. Hepatol. · Dec 2020
Oligosaccharide-dependent anti-inflammatory role of galectin-1 for macrophages in ulcerative colitis.
Galectin-1 plays a protective role against colitis by binding with polylactosamine structures on macrophages in β-1,4-galactosyltransferase I-deficient mice, but the precise function of galectin-1 remains unknown. In the present study, we investigated the anti-inflammatory role of galectin-1 on macrophages to ameliorate ulcerative colitis in both animal model and human tissue samples. ⋯ Galectin-1, whose expression is decreased in the inflamed mucosa of ulcerative colitis patients, can ameliorate murine colitis by conferring oligosaccharide-dependent anti-inflammatory properties to macrophages.