Journal of gastroenterology and hepatology
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J. Gastroenterol. Hepatol. · Feb 2020
Meta AnalysisPredictors of tolvaptan short-term response in patients with refractory ascites: A meta-analysis.
Tolvaptan represents an oral V2 -receptor antagonist, which has been suggested as a promising add-on diuretic treatment for refractory ascites. The present meta-analysis aims to accumulate current evidence and identify which clinical and laboratory factors are linked to short-term response to tolvaptan therapy. ⋯ The present findings suggest bodyweight, BUN, C-reactive protein, and hepatitis C as potential predictive factors of tolvaptan short-term response in patients with refractory ascites. Future studies are needed to introduce cut-off values and construct an optimal combined screening model.