Journal of gastroenterology and hepatology
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J. Gastroenterol. Hepatol. · Dec 2019
Circulating insulin-like growth factor binding protein-3 and risk of gastrointestinal malignant tumors.
Insulin-like growth factor-1 (IGF1) is a potent mitogen and is inhibited by IGF-binding protein-3 (IGFBP3). High serum IGF1 and low IGFBP3 are associated with increased risk of several carcinomas. Here, we assessed the relationship of these peptides with the risk of gastrointestinal malignancies, in a prospective case-control study nested in the Japan Collaborative Cohort Study. ⋯ Both total and free IGFBP3 may be inversely associated with the incidence of gastrointestinal malignancies.
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J. Gastroenterol. Hepatol. · Sep 2019
Association of low skeletal muscle mass with advanced liver fibrosis in patients with non-alcoholic fatty liver disease.
Although low skeletal muscle mass (LSMM) is known to increase the risk of non-alcoholic fatty liver disease (NAFLD), limited reports have described the relationship between LSMM and advanced fibrosis. Here, we investigated the association between LSMM and advanced liver fibrosis in NAFLD patients. ⋯ Low skeletal muscle mass is associated with advanced fibrosis in NAFLD patients independent of metabolic risk factors.
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J. Gastroenterol. Hepatol. · Aug 2019
Randomized Controlled Trial Comparative StudyComparison of polyp detection during both insertion and withdrawal versus only withdrawal of colonoscopy: A prospective randomized trial.
Polyps seen and not removed during colonoscope insertion are sometimes unable to be found during withdrawal. We aimed to evaluate whether additional inspection and polypectomy during insertion increases adenoma detection rate (ADR) compared with inspection and polypectomy entirely during withdrawal. ⋯ Additional inspection and polypectomy during colonoscope insertion did not improve ADR compared with inspection and polypectomy entirely during withdrawal. These results do not support an additional role for routine inspection during insertion (clinical trial registration number: NCT03444090).